A comparison of electrospray tandem mass spectra of some derivatives of sialic acid: ion trap and high resolution QqToF mass spectrometers
T13N2
A.O. Chizhov, A.M. Spirt1, N.Y. Savel’eva, L.O. Kononov
Using O-acetyl-N-acyl derivatives of O-methyl sialoside methyl esters it was shown that an ion trap and a hybrid analyzer (linear quadrupole — time-of-flight analyzer, reflectron) give comparable, though not identical secondary order mass spectra for the [M+Na]+ and [M+K]+ ions. A parallel use of an ion trap and a hybrid QqToF instrument makes possible to get information on fragmentation pathways of ions of sialic acid derivatives under collisional activation. In this case, a sequence of fragmentation may be established using an ion trap, whereas a QqToF instrument gives a possibility to reveal elemental composition of fragment ions quickly and unequivocally.
