Novel reactive matrices for analysis of alcohols by matrix-assisted laser desorption/ioization mass spectrometry
T15N2
M.S. Slyundina, R.S. Borisov, V.G. Zaikin
The possibility of using a number of aromatic and heteroaromatic carboxylic acids and their halogen anhydrides as reactive matrix compounds for the analysis of alcohols of different structures by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry has been studied. It is shown that acylation of alcohols with nicotinic and quinoline-6-carboxylic acid chlorides makes it possible to obtain derivatives having a high desorption/ionization efficiency under MALDI conditions, and the free acids formed as a result of the hydrolysis of anhydrides act as matrix compounds. The proposed approach is tested on a number of aliphatic, alicyclic and aromatic alcohols.
