High sensitive determination of 1,1-dimethylhydrazine by high-performance liquid chromatography – tandem mass-spectrometry with pre-column derivatization by phenylglyoxal
T12N4
S.V. Osipenko, R.S. Smirnov, A.D. Smolenkov, O.A. Shpigun
A new high sensitive and express approach to the determination of 1,1-dimethylhydrazine in natural water is developed (determination range is 0.03–1 µg L−1). It is based on the use of high-performance liquid chromatography – tandem mass-spectrometry with pre-column derivatization by phenylglyoxal and does not require any preconcentration. Derivatization, chromatographic separation conditions, and tandem mass-spectrometry detection parameters are chosen. Intra-day precision of the results of measurements of 1,1-dimethylhydrazine in natural water is 12−16 %, and inter-day precision is 16−22 %. Lowest limit of detection and lowest limit of quantitation are 0.010 µg L−1 and 0.030 µg L−1 respectively.
