Tris(2,6-dimethoxyphenyl)methyl carbenium ion as charge derivatization agent for the analysis of primary amines by MALDI mass spectrometry
T12N4
A.P. Topolyan, D.A. Strizhevskaya, M.S. Slyundina, M.A. Belyaeva, O.M. Ivanova,
V.A. Korshun, A.V. Ustinov, I.V. Mikhura, A.A. Formanovsky, R.S. Borisov
A novel derivatization method for the analysis of primary amines by MALDI mass spectrometry is proposed. Tris(2,6-dimethoxyphenyl)methyl carbenium cation reacts smoothly with primary amines forming permanently charged adducts with mass increment +359 Da and absorbance in UV region. The approach was tested on a number of amines including biologically active compounds and therapeutic agents.
