Review. Mass Spectrometry of physiologically active substances prohibited in Sports: The problem of screening a wide range of compounds and their metabolites

T14N3

E.D. Virus, A.V. Ivanov, D.P. Luzyanin, A.A. Kubatiev 

For the last 35 years, chromatography/mass spectrometry has been the main method of screening of physiologically active substances banned in sports. A characteristic feature of anti-doping control is the screening of a wide range of compounds with the applying of a large number of analytical procedures. This article introduces the reader to various approaches to the determination of physiologically active substances banned by World Anti-Doping Agency (WADA) using mass spectrometry. The article describes various aspects of the anti-doping control and the criteria under which substances are caught in the WADA list. A detailed description of the pharmacological properties of certain classes of prohibited substances in the article should help to purposefully identify the potential “candidates” for WADA list. Considering the intensity of replenishment of the WADA list with “new” classes of prohibited substances and significant time and material costs associated with the implementation of a large number of analytical procedures in doping control, the need to find new approaches to screening a wide range of bioregulators in anti-doping control is emphasized.

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