Silylation with the generation of a fixed charge for the analysis of alcohols by MALDI and SALDI mass spectrometry
T15N1
D.I. Zhilyaev, L.G. Voskresensky, N.Yu. Polovkov, R.S. Borisov
A new method of derivatization of alcohols for their analysis by matrix-assisted laser desorption/ionization (MALDI) and surface-assisted laser desorption/ionization (SALDI) is proposed. The approach is based on the silylation of the analytes by bromomethylchlorodimethylsilane in the presence of tertiary amines to yield the fixed-charge containing derivatives. The proposed method was tested using aliphatic, terpenoid and steroid alcohols. MALDI and SALDI mass spectra of all derivatives contained intense ion peaks corresponding to their cationic parts.
(Русский) Улучшенный подход к определению степени дериватизации
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