Determination of nerve agent hydrolysis products in natural waters by liquid chromatography/mass spectrometry
T12N2
I.A. Rodin, A.V. Braun, T.M. Baygildiev, I.A. Anan’eva, O.A. Shpigun, I.V. Rybalchenko
An approach to the determination of four nerve agents markers – S-(2-diethylaminoethyl) methylphosphonotioate, S-(2-diisopropylaminoethyl) methylphosphonotioate, bis (2-N,N-diethylaminoetil) disulfide and bis(2-N,N-diisopropylaminoethyl) disulfide – in aqueousenvironmental samples with the use of HPLC with tandem mass spectrometric detection was first developed. Optimal mass spectrometric detection and LC separation conditions were developed during the work. The proposed approach was applied to the analysis of real water samples and showed absence of matrix effect, good accuracy, reproducibility and selectivity. Detection limits achieved for S-(2-diethylaminoethyl) methylphosphonotioat, S-(2-diisopropylaminoethyl) methylphosphonotioat, bis(2-N,N-diethylaminoethyl) disulfide, and bis(2-N,N-diisopropylaminoethyl) disulfide in water samples were 0.0003, 0.003, 0.3 and 0.05 mg ml–1, respectively.
